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Description
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- Patients not currently taking methylphenidate:
- Initial: 18 to 36 mg orally once daily in the morning
- Patients currently taking immediate release (IR) methylphenidate or sustained release (SR) [Canadian product]:
- Initial: Note: Dosing based on current regimen and clinical judgment; suggested dosing listed below:
- IR methylphenidate: –
- Patients taking IR methylphenidate 5 mg 2 to 3 times daily: 18 mg orally once daily in the morning
- Patients taking IR methylphenidate 10 mg 2 to 3 times daily: 36 mg orally once daily in the morning
- Patients taking IR methylphenidate 15 mg 2 to 3 times daily: 54 mg orally once daily in the morning
- Patients taking IR methylphenidate 20 mg 2 to 3 times daily: 72 mg orally once daily in the morning
- SR methylphenidate (Concerta Canadian product labeling 2017):
- Patients taking methylphenidate SR 20 mg daily: 18 mg orally once daily in the morning
- Patients taking methylphenidate SR 40 mg daily: 36 mg orally once daily in the morning
- Patients taking methylphenidate SR 60 mg daily: 54 mg orally once daily in the morning
- Dose adjustment:
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- The dose may be increased in increments of 18 mg at weekly intervals.
- 27 mg dosage strength of is available for situations in which a dosage between 18 to 36 mg is desired.
- Maximum dose: 72 mg per 24 hours.
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- Patients not currently taking methylphenidate:
- Aptensio XR:
- Initial: 10 mg orally in OD dose; may titrate in 10 mg increments at weekly intervals; maximum: 60 mg per 24 hours.
- Biphentin [Canadian product]:
- Patients not currently taking methylphenidate:
- Initial: 10 to 20 mg orally in OD dose; may adjust in 10 mg increments at weekly intervals to a maximum dose of 80 mg per 24 hours.
- Conversion from immediate-release methylphenidate formulations to Biphentin:
- The equivalent total daily dose should be used & given in OD dose.
- Patients not currently taking methylphenidate:
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